Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites.

@article{Valentim2013GeneticAM,
  title={Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites.},
  author={Claudia L L Valentim and Donato Cioli and Fr{\'e}d{\'e}ric D Chevalier and Xiaohang Cao and Alexander Bryan Taylor and Stephen P. Holloway and Livia Pica-Mattoccia and Alessandra Guidi and Annalisa Basso and Isheng J Tsai and Matthew Berriman and Claudia Carvalho-Queiroz and Marcio Almeida and Hector R Aguilar and Doug E Frantz and Peter John Hart and Philip T. Loverde and Timothy J. C. Anderson},
  journal={Science},
  year={2013},
  volume={342 6164},
  pages={1385-9}
}
Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally derived second-generation progeny, and identified a single quantitative trait locus (logarithm of odds = 31) on chromosome 6… CONTINUE READING
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