Genetic and molecular basis of inflammasome-mediated disease.

@article{Hoffman2011GeneticAM,
  title={Genetic and molecular basis of inflammasome-mediated disease.},
  author={Hal M. Hoffman and Susannah D. Brydges},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 13},
  pages={10889-96}
}
The central function of IL-1 in fever regulation was recognized with its discovery 30 years ago (1). It was an attractive candidate as a master regulator in the pathogenesis of the hereditary fever syndromes; however, definitive proof was elusive. Themechanisms enablingmaturation and release of active IL-1 are complex, and it was difficult to detect the cytokine in patient serum. Validation of its central role in these rare autoinflammatory conditions was achieved in the last decade with the… CONTINUE READING
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