Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease.

@article{Cleynen2014GeneticAM,
  title={Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease.},
  author={Isabelle Cleynen and Emilie Vazeille and Marta Artieda and Hein W. Verspaget and Magdalena Szczypiorska and Marie-Agn{\'e}s Bringer and Peter L Lakatos and Frank W. Seibold and Kirstie S Parnell and Rinse K. Weersma and Jestinah M. Mahachie John and Rebecca Morgan-Walsh and Dominiek Staelens and Ingrid Arijs and Gert de Hertogh and Stefan M{\"u}ller and Atilla Tordai and Daniel W. Hommes and Tariq Ahmad and Cisca Wijmenga and Sylvia L.F. Pender and Paul J. Rutgeerts and Kristel Van Steen and Daniel Lottaz and S{\'e}verine Vermeire and Arlette Darfeuille-Michaud},
  journal={Gut},
  year={2014},
  volume={63 8},
  pages={
          1265-74
        }
}
OBJECTIVE Altered microbiota composition, changes in immune responses and impaired intestinal barrier functions are observed in IBD. Most of these features are controlled by proteases and their inhibitors to maintain gut homeostasis. Unrestrained or excessive proteolysis can lead to pathological gastrointestinal conditions. The aim was to validate the identified protease IBD candidates from a previously performed systematic review through a genetic association study and functional follow-up… CONTINUE READING
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