Genetic and metabolic determinants of plasma PCSK9 levels.

  title={Genetic and metabolic determinants of plasma PCSK9 levels.},
  author={Susan G. Lakoski and Thomas A. Lagace and Jonathan C. Cohen and Jay D. Horton and Helen H. Hobbs},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={94 7},
CONTEXT PCSK9 is a secreted protein that influences plasma levels of low-density lipoprotein cholesterol (LDL-C) and susceptibility to coronary heart disease. PCSK9 is present in human plasma, but the factors that contribute to differences in plasma concentrations of PCSK9 and how they impact on the levels of lipoproteins have not been well-characterized… CONTINUE READING