Genetic and in vitro assays of DNA deamination.

@article{Coker2006GeneticAI,
  title={Genetic and in vitro assays of DNA deamination.},
  author={Heather A. Coker and Hugh D. Morgan and Svend K. Petersen-Mahrt},
  journal={Methods in enzymology},
  year={2006},
  volume={408},
  pages={
          156-70
        }
}
The DNA deaminase family encompasses enzymes that have been highly conserved throughout vertebrate evolution and which display wide-ranging positive effects upon innate and adaptive immune system and development. Activation-induced cytidine deaminase was identified as a DNA mutator after its necessity in the successful development of high-affinity B cells via somatic hypermutation, class switch recombination, and gene conversion was determined. APOBEC3 exhibits the ability to deaminate… CONTINUE READING
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