Genetic and immunologic characterization of a novel serotype 4, 15 strain of Neisseria meningitidis.

@article{Bash2000GeneticAI,
  title={Genetic and immunologic characterization of a novel serotype 4, 15 strain of Neisseria meningitidis.},
  author={Margaret C. Bash and Freyja Lynn and Nelydia F Concepcion and Jordan W. Tappero and George M. Carlone and Carl E. Frasch},
  journal={FEMS immunology and medical microbiology},
  year={2000},
  volume={29 3},
  pages={
          169-76
        }
}
The porin proteins of Neisseria meningitidis are important components of outer membrane protein (OMP) vaccines. The class 3 porin gene, porB, of a novel serogroup B, serotype 4, 15 isolate from Chile (Ch501) was found to be VR1-4, VR2-15, VR3-15 and VR4-15 by porB variable region (VR) typing. Rabbit immunization studies using outer membrane vesicles revealed immunodominance of individual PorB (class 3) VR epitopes. The predominant anti-Ch501 PorB response was directed to the VR1 epitope. Anti… CONTINUE READING