Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

@article{Greene2005GeneticAG,
  title={Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.},
  author={Jessica C. Greene and Alexander J Whitworth and Laurie A. Andrews and Tracey J Parker and Leo J Pallanck},
  journal={Human molecular genetics},
  year={2005},
  volume={14 6},
  pages={799-811}
}
Loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase, are a common cause of autosomal recessive juvenile parkinsonism (ARJP). Previous work has led to the identification of a number of Parkin substrates that implicate specific pathways in ARJP pathogenesis, including endoplasmic reticulum (ER) stress and cell cycle activation. To test the involvement of previously implicated pathways, as well as to identify novel pathways in ARJP pathogenesis, we are using… CONTINUE READING

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