Genetic and functional relationships between MHC and NK receptor genes.

  title={Genetic and functional relationships between MHC and NK receptor genes.},
  author={John Trowsdale},
  volume={15 3},
HLA class I and NK receptors are encoded within dense clusters of immune loci. The MHC, at 6p21.3, and the complex containing the KIR loci, at 19q13.4, both feature variation in the number of genes, as well as sequence polymorphism. In addition to T cell receptors, several variable class I-related molecules interact with polymorphic NK receptors. Some of the lectin-related NK receptor genes, at 12p13.1, also have ligands belonging to the extended class I family. The expanding clusters of class… CONTINUE READING

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