Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway.

@article{He2006GeneticAF,
  title={Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway.},
  author={Yi He and Reiko Sugiura and Yan Ma and Ayako Kita and Lu Deng and Kaoru Takegawa and Ken Matsuoka and Hisato Shuntoh and Takayoshi Kuno},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2006},
  volume={11 3},
  pages={207-21}
}
We have previously isolated ypt3-i5 mutant and showed that Ypt3 GTPase functions in the fission yeast secretory pathway. Here, the same genetic screen led to the isolation of ryh1-i6, a mutant allele of the ryh1+ gene encoding a homolog of Rab6. The ryh1-i6 mutant showed phenotypes that support its role in retrograde traffic from endosome to the Golgi. Interestingly, ryh1+ gene deletion was synthetically lethal with ypt3-i5 mutation. Consistently, the over-expression of the GDP-conformational… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling.

Genes to cells : devoted to molecular & cellular mechanisms • 2014
View 7 Excerpts

Similar Papers

Loading similar papers…