Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility

@article{Alter2009GeneticAF,
  title={Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility},
  author={A. J. Alter and Louis de L{\'e}s{\'e}leuc and Nguyen Van Thuc and Vu Hong Thai and Nguyen Thi Thu Huong and Nguyen Ngoc Ba and Cynthia Chester Cardoso and Audrey V. Grant and Laurent Abel and Milton Oz{\'o}rio Moraes and Alexandre Alca{\"i}s and Erwin Schurr},
  journal={Human Genetics},
  year={2009},
  volume={127},
  pages={337-348}
}
The chromosomal region 10p13 has been linked to paucibacillary leprosy in two independent studies. The MRC1 gene, encoding the human mannose receptor (MR), is located in the 10p13 region and non-synonymous SNPs in exon 7 of the gene have been suggested as leprosy susceptibility factors. We determined that G396S is the only non-synonymous exon 7-encoded… CONTINUE READING