Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism

@article{Pilorge2016GeneticAF,
  title={Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism},
  author={Marion Pilorge and Coralie Fassier and H Le Corronc and Anais Potey and Jia-min Bai and Sharize Cristine de Araujo Gois and Elsa Delaby and Brigitte Assouline and Vincent Guinchat and Françoise Devillard and Richard Delorme and Gudrun Nygren and Maria R{\aa}stam and Jochen C Meier and Sanae Otani and H{\'e}l{\`e}ne Cheval and Victoria M. James and Maya Topf and T. Neil Dear and Christopher Gillberg and Marion Leboyer and Bruno Giros and Sophie Gautron and Jamil{\'e} Hazan and Robert J Harvey and Pascal Legendre and Catalina Betancur},
  journal={Molecular Psychiatry},
  year={2016},
  volume={21},
  pages={936-945}
}
Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by marked genetic heterogeneity. Recent studies of rare structural and sequence variants have identified hundreds of loci involved in ASD, but our knowledge of the overall genetic architecture and the underlying pathophysiological mechanisms remains incomplete. Glycine receptors (GlyRs) are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system but exert an… CONTINUE READING

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