Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells

  title={Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells},
  author={Hee-Jung Yoo and Bo-Ra Yun and Jung-Hee Kwon and Hyuk-Soo Ahn and Min-A Seol and Mi-jin Lee and Goung-Ran Yu and H Yu and BeeHak Hong and KwanYong Choi and Dae-Ghon Kim},
  journal={Experimental & Molecular Medicine},
Cholangiocarcinoma (CC) is an intrahepatic bile duct carcinoma with a high mortality rate and a poor prognosis. Sarcomatous change/epithelial mesenchymal transition (EMT) of CC frequently leads to aggressive intrahepatic spread and metastasis. The aim of this study was to identify the genetic alterations and gene expression pattern that might be associated with the sarcomatous change in CC. Previously, we established 4 human CC cell lines (SCK, JCK1, Cho-CK, and Choi-CK). In the present study… CONTINUE READING
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