Genetic and expression aberrations of E3 ubiquitin ligases in human breast cancer.

@article{Chen2006GeneticAE,
  title={Genetic and expression aberrations of E3 ubiquitin ligases in human breast cancer.},
  author={Ceshi Chen and A. K. Seth and Andrew E. Aplin},
  journal={Molecular cancer research : MCR},
  year={2006},
  volume={4 10},
  pages={695-707}
}
Recent studies revealed that E3 ubiquitin ligases play important roles in breast carcinogenesis. Clinical research studies have found that (epi)-genetic (deletion, amplification, mutation, and promoter methylation) and expression aberration of E3s are frequent in human breast cancer. Furthermore, many studies have suggested that many E3s are either oncogenes or tumor suppressor genes in breast cancer. In this review, we provide a comprehensive summary of E3s, which have genetic and/or… CONTINUE READING

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