Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors


Beclin 1, an important autophagy-related protein in human cells, is involved in cell death and cell survival. Beclin 1 mapped to human chromosome 17q21. It is widely expressed in normal mammary epithelial cells. Although down-regulated expression with mono-allelic deletions of beclin 1 gene was frequently observed in breast tumors, whether there was other… (More)
DOI: 10.1186/1471-2407-10-98

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