Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers.

@article{Iijima2006GeneticAE,
  title={Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers.},
  author={Hironobu Iijima and Yoshio Tomizawa and Yasuki Iwasaki and Koji Sato and Noriaki Sunaga and Kunio Dobashi and Ryusei Saito and Takashi Nakajima and John D. Minna and Masatomo Mori},
  journal={International journal of cancer},
  year={2006},
  volume={118 4},
  pages={797-801}
}
Allelic loss on the short arm of chromosome 3 is one of the most common events in the pathogenesis of lung cancer. The lactotransferrin gene (LTF, also referred to as the lactoferrin gene, LF) is located at 3p21.3 common eliminated region 1, which is frequently deleted in lung and other cancers. The expression of the LTF gene was absent in 16 (59%) of 27… CONTINUE READING