Genetic and epigenetic characterization of low-grade gliomas reveals frequent methylation of the MLH3 gene.

@article{Lhotska2015GeneticAE,
  title={Genetic and epigenetic characterization of low-grade gliomas reveals frequent methylation of the MLH3 gene.},
  author={Halka Lhotska and Zuzana Zemanova and Hana Cechova and S{\'a}rka Ransdorfov{\'a} and Libuse Lizcov{\'a} and Filip Kramar and Zdenek Krejc{\'i}k and Karla Svobodov{\'a} and Dagmar Bystřick{\'a} and Petr Hrabal and Alena Dohnalov{\'a} and Kyra Michalov{\'a}},
  journal={Genes, chromosomes & cancer},
  year={2015},
  volume={54 11},
  pages={
          655-67
        }
}
Diffuse astrocytomas and oligodendrogliomas (WHO grade II) are the most common histological subtypes of low-grade gliomas (LGGs). Several molecular and epigenetic markers have been identified that predict tumor progression. Our aim was in detail to investigate the genetic and epigenetic background of LGGs and to identify new markers that might play a role in tumor behavior. Twenty-three patients with oligodendroglioma or oligoastrocytoma (LGO) and 22 patients with diffuse astrocytoma (LGA) were… CONTINUE READING
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