Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.

  title={Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.},
  author={Tetyana V Bagnyukova and Volodymyr P. Tryndyak and Beverly Montgomery and Mona I. Churchwell and Adam R. Karpf and Smitha R. James and Levan Muskhelishvili and Frederick A Beland and Igor P Pogribny},
  volume={29 3},
Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify the role of carcinogens in both the genetic and epigenetic changes in premalignant tissues and a lack of conclusive information on the link between epigenetic alterations and… CONTINUE READING


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The epigenomics of cancer

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Effect of long - term tamoxifen exposure on genotoxic and epigenetic changes in rat liver : implications for tamoxifen - induced hepatocarcinogenesis

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Carcinogenesis • 2006

Molecular mechanisms of human carcinogenesis

K. Tokumo
EXS • 2006

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