Genetic and epigenetic basis of psoriasis pathogenesis.

  title={Genetic and epigenetic basis of psoriasis pathogenesis.},
  author={Aditi Chandra and Aditi Ray and Swapan Senapati and Raghunath Chatterjee},
  journal={Molecular immunology},
  volume={64 2},
Psoriasis is a chronic inflammatory skin disease whose prevalence varies among different populations worldwide. It is a complex multi-factorial disease and the exact etiology is largely unknown. Family based studies have indicated a genetic predisposition; however they cannot fully explain the disease pathogenesis. In addition to genetic susceptibility, environmental as well as gender and age related factors were also been found to be associated. Recently, imbalances in epigenetic networks are… CONTINUE READING