Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers.

  title={Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers.},
  author={Jae Hwi Song and Chang Jae Kim and Yong Gu Cho and Hyun Jung Kwak and Suk Woo Nam and Nam Jin Yoo and Jung Young Lee and Won Sang Park},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={115 2},
EPHB2 is a member of the Eph receptor tyrosine kinase family and a direct transcriptional target of beta-catenin/TCF. EPHB2 plays an important role in maintaining the correct positioning of the proliferative compartment in the crypt-villous axis. A loss of EPHB2 expression has been observed in human tumors, particularly in colonic adenomas and carcinomas. A search was made for mutations at the A9 tract in exon 17, an allelic loss at the EPHB2 gene locus, and promoter hypermethylation of the… CONTINUE READING

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