Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer.

@article{Hoque2010GeneticAE,
  title={Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer.},
  author={Mohammad Obaidul Hoque and Mariana Brait and Eli Rosenbaum and Maria Luana Poeta and Prodipto Pal and S. Shabana Begum and Santanu Dasgupta and Andr{\'e} Lopes Carvalho and Steven A. Ahrendt and William H Westra and David Sidransky},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2010},
  volume={5 12},
  pages={
          1887-93
        }
}
BACKGROUND Prognosis for patients with non-small cell lung cancer (NSCLC) is poor. The potential value of modulating epidermal growth factor receptor (EGFR) for treatment is reflected by the recent approval of specific drugs that inhibit its activity. Mutations in EGFR were reported in lung cancer and generated interest, once they enable the identification of lung cancers likely to respond to various targeted small molecules. METHODS We tested three key genetic and epigenetic alterations… CONTINUE READING

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