Genetic and epigenetic alterations of steroidogenic factor-1 in ovarian tumors

@inproceedings{Miller2013GeneticAE,
  title={Genetic and epigenetic alterations of steroidogenic factor-1 in ovarian tumors},
  author={Sarah Miller and Nobel Bhasin and HEATHER URREGO and Krzysztof Moroz and Brian G. Rowan and Meera S. Ramayya and Nick M. Makridakis},
  booktitle={International journal of oncology},
  year={2013}
}
Steroidogenic factor-1 (SF‑1), the product of the NR5A1 gene, is an essential transcription factor that is known to regulate steroidogenesis in ovarian epithelia, including the synthesis of progesterone, a suppressor of ovarian cancer. Expression of the SF‑1 protein, a potential ovarian tumor suppressor, has been demonstrated in normal OSE cells, but is lost in most ovarian tumors and ovarian tumor cell lines. We examined loss of… CONTINUE READING
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