Genetic and epigenetic alterations of WWOX in the development of gastric cardia adenocarcinoma.


WWOX is a tumor suppressor gene that maps to the common fragile site FRA16D and is involved in carcinogenesis and cancer progression in many different carcinomas. Reduced WWOX expression is associated with more aggressive phenotypes and poor patient outcomes in several cancers. The present study was conducted in order to elucidate more precisely the genetic… (More)
DOI: 10.1002/em.21748


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