Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors.

@article{Cavalli2003GeneticAE,
  title={Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors.},
  author={Luciane Regina Cavalli and C{\'i}cero de Andrade Urban and Dongqiu Dai and Sonia de Assis and Denise Crispim Tavares and Janice D. Rone and Luiz Fernando Bleggi-Torres and Rubens Silveira de Lima and Iglenir Jo{\~a}o Cavalli and Jean Pierre J Issa and Bassem R. Haddad},
  journal={Cancer genetics and cytogenetics},
  year={2003},
  volume={146 1},
  pages={33-40}
}
The accumulation of genetic and epigenetic changes plays a pivotal role in tumor development and progression. In this study, we investigated these changes using comparative genomic hybridization and bisulfite polymerase chain reaction analysis for CpG island hypermethylation of the following genes: TP16, THBS2, E-Cadherin (ECAD), RARbeta2, MINT1, MINT2, and MINT31 in six paired primary breast tumors and their matched sentinel lymph nodes (SLN). The most frequent chromosomal alterations observed… CONTINUE READING

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