Genetic and epigenetic X-chromosome variations in a parthenogenetic human embryonic stem cell line

@article{Liu2010GeneticAE,
  title={Genetic and epigenetic X-chromosome variations in a parthenogenetic human embryonic stem cell line},
  author={Weiqiang Liu and Yifei Yin and Yonghua Jiang and Chaohui Kou and Yumei Luo and Shengchang Huang and Yuhong Zheng and Shaoying Li and Qing Li and Liyuan Guo and Shaorong Gao and Xiaofang Sun},
  journal={Journal of Assisted Reproduction and Genetics},
  year={2010},
  volume={28},
  pages={303-313}
}
To assess the genetic and epigenetic status of parthenogenetic human embryonic stem cells (phESCs). Cytogenetics, X chromosome inactivation (XCI) and gene expression patterns were analyzed in one phESC line (FY-phES-018) that was derived from our laboratory. FY-phES-018 cells displayed the classical characteristics of normal hESCs. These cells had a 46, XX karyotype, and no inactive X chromosomes were observed before passage 20. After being cultured long term in vitro, some cells lost one X… CONTINUE READING
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