Genetic and environmental risk factors for oral anticoagulant overdose

  title={Genetic and environmental risk factors for oral anticoagulant overdose},
  author={C{\'e}line Verstuyft and Annie Robert and Sandrine Morin and Marie Anne Loriot and Antoine Flahault and Philippe H. Beaune and Christian Funck-Brentano and P. Jaillon and Laurent Becquemont},
  journal={European Journal of Clinical Pharmacology},
Background. Cytochrome P 450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. Objectives. To determine the relative frequencies of different risk factors for OA overdose including diet, concomitant diseases, drug interactions, recent increment of OA dose and CYP2C9 genetic polymorphism among hospitalised patients. Materials and methods. Frequencies of the… CONTINUE READING


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