Genetic and environmental risk factors for rheumatoid arthritis.

  title={Genetic and environmental risk factors for rheumatoid arthritis.},
  author={Kevin D. Deane and M Kristen Demoruelle and Lindsay B Kelmenson and Kristine A Kuhn and Jill M Norris and V. Michael Holers},
  journal={Best practice & research. Clinical rheumatology},
  volume={31 1},
Multiple genetic and environmental factors have been associated with an increased risk for rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female sex, a family history of RA, the genetic factor the "shared epitope," and exposure to tobacco smoke. There is also renewed interest in mucosal inflammation and microbial factors… CONTINUE READING