Genetic and environmental influences of surfactant protein D serum levels.

  title={Genetic and environmental influences of surfactant protein D serum levels.},
  author={Grith Lykke S\orensen and Jacob v. B. Hjelmborg and Kirsten Ohm Kyvik and Mogens Fenger and Anette H\oj and Christian Bendixen and Thorkild I. A. S\orensen and Uffe Holmskov},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={290 5},
The collectin surfactant protein D (SP-D) is an important component of the pulmonary innate immune system, but SP-D is also present on extrapulmonary epithelial surfaces and in serum, where it has been used as a biomarker for pulmonary disease states. In this study, we investigate the mechanisms defining the constitutional serum level of SP-D and determine the magnitude of the genetic contribution to serum SP-D in the adult population. Recent studies have demonstrated that serum SP-D… CONTINUE READING
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