Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1.

@article{Deakin2004GeneticAE,
  title={Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1.},
  author={Sara P Deakin and R. W. James},
  journal={Clinical science},
  year={2004},
  volume={107 5},
  pages={
          435-47
        }
}
PON1 (paraoxonase-1) is an HDL (high-density lipoprotein)-associated enzyme capable of hydrolysing diverse substrates from OP (organophosphate) toxins to oxidized phospholipids. As such, it has been linked with both the prevention of OP poisoning and inhibition of atherosclerosis initiated by oxidatively modified LDL (low-density lipoprotein). Mice deficient in PON1 are more susceptible to OP poisoning and oxidative stress and more prone to develop atherosclerosis than their wild-type siblings… CONTINUE READING

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