Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.

@article{Jorgensen2009GeneticAE,
  title={Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study.},
  author={Andrea L. Jorgensen and Sameh A Al-Zubiedi and Jieying Eunice Zhang and Andrew Keniry and Anita Hanson and Dyfrig A Hughes and Diane van Eker and Lisa P Stevens and Karen S. Hawkins and Cheng Hock Toh and Farhad Kamali and Ann K Daly and David Fitzmaurice and Alison Coffey and Paula R Williamson and Brian Kevin Park and Panagiotis Deloukas and Munir Pirmohamed},
  journal={Pharmacogenetics and genomics},
  year={2009},
  volume={19 10},
  pages={800-12}
}
BACKGROUND In this prospective cohort study, we have undertaken a comprehensive evaluation of clinical parameters along with variation in 29 genes (including CYP2C9 and VKORC1) to identify factors determining interindividual variability in warfarin response. METHODS Consecutive patients (n=311) were followed up prospectively for 26 weeks. Several outcomes chosen to capture both warfarin efficacy and toxicity were assessed. Univariate and multiple regression analyses were undertaken to assess… CONTINUE READING
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