Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand.

@article{Honjo2005GeneticAE,
  title={Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand.},
  author={Satoshi Honjo and Petcharin Srivatanakul and Hutcha Sriplung and Hiroko Kikukawa and Shuji Hanai and Kazuhiko Uchida and Takeshi Todoroki and Adisorn Jedpiyawongse and Pacharin Kittiwatanachot and Banchob Sripa and Somyos Deerasamee and Masanao Miwa},
  journal={International journal of cancer},
  year={2005},
  volume={117 5},
  pages={854-60}
}
Infection with Opisthorchis viverrini (OV) is associated with cholangiocarcinoma. OV is common in northeast Thailand, but less than 10% of the inhabitants develop cholangiocarcinoma. Animal experiments suggest that OV infection alone does not cause cholangiocarcinoma, and thus other environmental and genetic factors may play a role in causation. We conducted a population-based case-control study in which sex, age and place of residence were matched individually. Polymorphisms of GSTM1 and GSTT1… CONTINUE READING
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