Genetic and environmental backgrounds responsible for the changes in the phenotype of MS in Japanese subjects.

@article{Kira2012GeneticAE,
  title={Genetic and environmental backgrounds responsible for the changes in the phenotype of MS in Japanese subjects.},
  author={Jun-ichi Kira},
  journal={Multiple sclerosis and related disorders},
  year={2012},
  volume={1 4},
  pages={188-95}
}
There are two distinct phenotypes of multiple sclerosis (MS) in Asians, manifesting as opticospinal (OSMS) and conventional (CMS) forms. In Japan, the results of four nationwide surveys of MS conducted between 1972 and 2004 have revealed a four-fold increase in the estimated number of clinically definite MS patients in 2003 compared with 1972; a shift in the peak age at onset from the early 30s in 1989 to the early 20s in 2003; a successive proportional decrease in optic-spinal involvement in… CONTINUE READING

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