Genetic and dietary adaptation to malaria in human populations.

  title={Genetic and dietary adaptation to malaria in human populations.},
  author={Lawrence S. Greene},
  volume={41 1-3},
Plasmodial invasion places a severe oxidant stress on parasitized erythrocytes which can result in red cell damage and removal within the reticuloendothelial system or lysis, thus interrupting the parasitic cycle. The basis of a number of genetic adaptations to malaria--including the hemoglobin variants, the thalassemias, and glucose-6-phosphate dehydrogenase deficiency--is an increased sensitivity of the variant erythrocytes to the oxidant stress of plasmodial parasitization. It is suggested… CONTINUE READING