Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

@inproceedings{Wagener2010GeneticAD,
  title={Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity},
  author={Asja Wagener and Helge F Goessling and Armin O. Schmitt and Susanne Mauel and Achim D Gruber and Richard Reinhardt and Gudrun A. Brockmann},
  booktitle={Lipids in Health and Disease},
  year={2010}
}
The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different Ppar genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes. At the age of 10 weeks, the BFMI mice exhibited marked obesity with… CONTINUE READING