Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans

@article{Alpi2003GeneticAC,
  title={Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans},
  author={Arno Alpi and Pawel Pasierbek and Anton Gartner and Josef Loidl},
  journal={Chromosoma},
  year={2003},
  volume={112},
  pages={6-16}
}
We investigated the role of Caenorhabditis elegans rad-51 during meiotic prophase. We showed that rad-51 mutant worms are viable, have no defects in meiotic homology recognition and synapsis but exhibit abnormal chromosomal morphology and univalent formation at diakinesis. During meiosis RAD-51 becomes localized to distinct foci in nuclei of the transition zone of the gonad and is most abundant in nuclei at late zygotene/early pachytene. Foci then gradually disappear from chromosomes and no… CONTINUE READING
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