Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.

@article{Dai2005GeneticAC,
  title={Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.},
  author={Xinhua Dai and Ken-Ichiro Hayashi and Hiroshi Nozaki and Youfa Cheng and Yunde Zhao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 8},
  pages={
          3129-34
        }
}
The synthetic molecule sirtinol was shown previously to activate the auxin signal transduction pathway. Here we present a combination of genetic and chemical approaches to elucidate the action mechanisms of sirtinol in Arabidopsis. Analysis of sirtinol derivatives indicated that the "active moiety" of sirtinol is 2-hydroxy-1-naphthaldehyde (HNA), suggesting that sirtinol undergoes a series of transformations in Arabidopsis to generate HNA, which then is converted to 2-hydroxy-1-naphthoic acid… CONTINUE READING
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