Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management.

@article{Bacigaluppi2013GeneticAC,
  title={Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management.},
  author={Susanna Bacigaluppi and Saverio Francesco Retta and Silvana Pileggi and Marco Fontanella and Luca Goitre and Laura Tassi and Alessandro La Camera and Alberto Citterio and Maria Cristina Patrosso and Giovanni Tredici and Silvana Penco},
  journal={Clinical genetics},
  year={2013},
  volume={83 1},
  pages={7-14}
}
Cerebral cavernous malformations (CCMs) are a diffuse cerebrovascular disease affecting approximately 0.5% of the population. A CCM is characterized by abnormally enlarged and leaky capillaries arranged in mulberry-like structures with no clear flow pattern. The lesion might predispose to seizures, focal neurological deficits or fatal intracerebral hemorrhage. However, a CCM can also remain neurologically silent. It might either occur sporadically or as an inherited disorder with incomplete… CONTINUE READING
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