Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications.

@article{Lippi2009GeneticAB,
  title={Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications.},
  author={Giuseppe Lippi and Giovanni Targher and Massimo Franchini and Mario Plebani},
  journal={Clinical chemistry and laboratory medicine},
  year={2009},
  volume={47 10},
  pages={1183-94}
}
The contractile sarcomeric pool of skeletal muscle and heart consists of a highly-ordered arrangement of actin thin filaments, tropomyosin and proteins of the troponin complex: troponin I (TnI), troponin T (TnT) and troponin C (TnC). The cardiac myocyte expresses specific isoforms of both TnI and TnT (cTnI and cTnT, respectively), which can be distinguished from skeletal muscle isoforms by rapid and reliable immunoassays. Due to their superior cardiac specificity, cTnI and cTnT have become the… CONTINUE READING

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