Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.

@article{Archambault2003GeneticAB,
  title={Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.},
  author={Vincent Archambault and Caihong X Li and Alan J. Tackett and Ralph Wasch and Brian T Chait and Michael P. Rout and Frederick R Cross},
  journal={Molecular biology of the cell},
  year={2003},
  volume={14 11},
  pages={
          4592-604
        }
}
We evaluated the hypothesis that the N-terminal region of the replication control protein Cdc6 acts as an inhibitor of cyclin-dependent kinase (Cdk) activity, promoting mitotic exit. Cdc6 accumulation is restricted to the period from mid-cell cycle until the succeeding G1, due to proteolytic control that requires the Cdc6 N-terminal region. During late mitosis, Cdc6 is present at levels comparable with Sic1 and binds specifically to the mitotic cyclin Clb2. Moderate overexpression of Cdc6… CONTINUE READING

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