Genetic and biochemical diversity in the Pax gene family.

  title={Genetic and biochemical diversity in the Pax gene family.},
  author={Darrell Alan Underhill},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={78 5},
The mammalian Pax gene family comprises nine members that are characterized by a conserved DNA-binding motif, the paired domain, which was originally described in the Drosophila protein paired. Both loss- and gain-of-function studies reveal that Pax genes carry out essential roles during embryogenesis, and in some instances, may function as master… CONTINUE READING