Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

@article{Rosenbluh2016GeneticAP,
  title={Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.},
  author={Joseph Rosenbluh and Johnathan Mercer and Yashaswi Shrestha and R A Oliver and Pablo Tamayo and John G Doench and Itay Tirosh and Federica Piccioni and Ella Hartenian and Heiko Horn and Lola Fagbami and David E Root and Jacob D. Jaffe and Kasper Lage and Jesse S Boehm and William C. Hahn},
  journal={Cell systems},
  year={2016},
  volume={3 3},
  pages={
          302-316.e4
        }
}
Genome-scale expression studies and comprehensive loss-of-function genetic screens have focused almost exclusively on the highest confidence candidate genes. Here, we describe a strategy for characterizing the lower confidence candidates identified by such approaches. We interrogated 177 genes that we classified as essential for the proliferation of cancer cells exhibiting constitutive β-catenin activity and integrated data for each of the candidates, derived from orthogonal short hairpin RNA… CONTINUE READING
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