Genetic and Proteomic Evidence for Roles of Drosophila SUMO in Cell Cycle Control, Ras Signaling, and Early Pattern Formation

@article{Nie2009GeneticAP,
  title={Genetic and Proteomic Evidence for Roles of Drosophila SUMO in Cell Cycle Control, Ras Signaling, and Early Pattern Formation},
  author={M. Nie and Yongming Xie and J. Loo and A. Courey},
  journal={PLoS ONE},
  year={2009},
  volume={4}
}
SUMO is a protein modifier that is vital for multicellular development. Here we present the first system-wide analysis, combining multiple approaches, to correlate the sumoylated proteome (SUMO-ome) in a multicellular organism with the developmental roles of SUMO. Using mass-spectrometry-based protein identification, we found over 140 largely novel SUMO conjugates in the early Drosophila embryo. Enriched functional groups include proteins involved in Ras signaling, cell cycle, and pattern… Expand
Emerging roles of the SUMO pathway in development
SUMOylation in Drosophila Development
Sumo in development: lessons from drosophila with comparisons to mammals
SUMO in Drosophila Development.
The SUMO pathway functions in mouse oocyte maturation
A conserved SUMOylation signaling for cell cycle control in a holocentric species Bombyx mori.
Developmental transcriptional regulation by SUMOylation, an evolving field
The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 92 REFERENCES
Expression of genes involved in sumoylation in the Drosophila germline.
Emerging roles of the SUMO pathway in mitosis
  • M. Dasso
  • Biology, Medicine
  • Cell Division
  • 2008
Defining the SUMO-modified Proteome by Multiple Approaches in Saccharomyces cerevisiae*
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.
Ubc9 regulates mitosis and cell survival during zebrafish development.
Sumoylation regulates diverse biological processes
  • J. Zhao
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 2007
Global Analyses of Sumoylated Proteins in Saccharomyces cerevisiae
Global Analysis of Protein Sumoylation in Saccharomyces cerevisiae*
Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.
A Proteomic Strategy for Gaining Insights into Protein Sumoylation in Yeast*S
...
1
2
3
4
5
...