Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior

@article{Mombereau2004GeneticAP,
  title={Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior},
  author={C{\'e}dric Mombereau and Klemens Kaupmann and Wolfgang Froestl and Gilles Sansig and H. W. H. M. van der Putten and John F Cryan},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={1050-1062}
}
Although there is much evidence for a role of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the pathophysiology of anxiety and depression, the role of GABAB receptors in behavioral processes related to these disorders has not yet been fully established. GABAB receptors are G-protein-coupled receptors, which act as functional heterodimers made up of GABAB(1) and GABAB(2) subunits. Using recently generated GABAB(1) −/− mice, which lack functional GABAB receptors, and… CONTINUE READING
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