Genetic and Infectious Profiles of Japanese Multiple Sclerosis Patients

  title={Genetic and Infectious Profiles of Japanese Multiple Sclerosis Patients},
  author={Satoshi Yoshimura and Noriko Isobe and Tomomi Yonekawa and Takuya Matsushita and Katsuhisa Masaki and Shinya Sato and Yuji Kawano and Ken Yamamoto and Jun-ichi Kira},
  booktitle={PloS one},
BACKGROUND Nationwide surveys conducted in Japan over the past thirty years have revealed a four-fold increase in the estimated number of multiple sclerosis (MS) patients, a decrease in the age at onset, and successive increases in patients with conventional MS, which shows an involvement of multiple sites in the central nervous system, including the cerebrum and cerebellum. We aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of MS in Japanese… CONTINUE READING
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