Genetic and Hormonal Regulation of Tryptophan–Kynurenine Metabolism

@article{Oxenkrug2007GeneticAH,
  title={Genetic and Hormonal Regulation of Tryptophan–Kynurenine Metabolism},
  author={Gregory F Oxenkrug},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122}
}
  • G. Oxenkrug
  • Published 1 December 2007
  • Biology
  • Annals of the New York Academy of Sciences
Impairment of cognition that is caused by (or associated with) vascular factors has been termed vascular cognitiveimpairment (VCI). The hallmark of VCI is an impairment of brain executive, or planning, functions caused by inflammatory changes of brain microvessels. VCI is characterized by impairment of the executive function and is distinct from Alzheimer's‐type and multi‐infarct dementias, although VCI might overlap with Alzheimer's disease. This review focuses on the possible contribution of… 
Metabolic syndrome, age‐associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism
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KYN–TRY metabolism might be the meeting point for gene‐environment interaction and a new target for prevention and treatment of MetS/AAND.
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Pharmacological modulation of KP pathways has shown encouraging results, indicating that it may be a viable and explorable target for the therapy of AD.
Insulin Resistance and Dysregulation of Tryptophan–Kynurenine and Kynurenine–Nicotinamide Adenine Dinucleotide Metabolic Pathways
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It is proposed that one of the mechanisms of IR is inflammation- and/or stress-induced upregulation of TRP–KYN metabolism in combination with P5P deficiency-induced diversion of KYN–NAD metabolism towards formation of XA and other KYN derivatives affecting insulin activity.
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Targeting the kynurenine pathway offers a valuable strategic option for the attenuation of glutamatergic excitotoxicity, and for neuroprotection.
Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives
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This review considers various methods through which enzymes and metabolites of the kynurenine pathway influence the immune system, the roles they play in the pathogenesis of neuroinflammatory diseases based on current evidence with a focus on their involvement in multiple sclerosis, as well as therapeutic approaches.
Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications
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The purpose of this review is to survey the recent literature addressing the kynurenine pathway of tryptophan degradation in CVD, and the author will direct attention to the function performed by IDO1-mediated tryPTophan metabolism.
The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors
TLDR
Targeting the kynurenine pathway offers a valuable strategic option for the attenuation of glutamatergic excitotoxicity, and for neuroprotection.
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders
This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)–kynurenine (KYN) and
Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.
  • G. Oxenkrug
  • Biology, Psychology
    The Israel journal of psychiatry and related sciences
  • 2010
TLDR
The present review of genetic and hormonal factors regulating kynurenine pathway of tryptophan metabolism suggests that this pathway mediates both genetic and environmental mechanisms of depression.
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