Genetic and Hormonal Regulation of Tryptophan–Kynurenine Metabolism

@article{Oxenkrug2007GeneticAH,
  title={Genetic and Hormonal Regulation of Tryptophan–Kynurenine Metabolism},
  author={G. Oxenkrug},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122}
}
  • G. Oxenkrug
  • Published 2007
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • Impairment of cognition that is caused by (or associated with) vascular factors has been termed vascular cognitiveimpairment (VCI). The hallmark of VCI is an impairment of brain executive, or planning, functions caused by inflammatory changes of brain microvessels. VCI is characterized by impairment of the executive function and is distinct from Alzheimer's‐type and multi‐infarct dementias, although VCI might overlap with Alzheimer's disease. This review focuses on the possible contribution of… CONTINUE READING
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    References

    SHOWING 1-10 OF 75 REFERENCES
    Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
    • 493
    • PDF
    Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection
    • 390
    Cytokines in dementias.
    • E. Tarkowski
    • Medicine
    • Current drug targets. Inflammation and allergy
    • 2002
    • 38
    Endogenous neurotoxins from tryptophan.
    • T. Stone
    • Biology, Medicine
    • Toxicon : official journal of the International Society on Toxinology
    • 2001
    • 125
    Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety.
    • I. Lapin
    • Medicine, Biology
    • Advances in experimental medicine and biology
    • 2003
    • 57
    Antioxidant effects of N-acetylserotonin: possible mechanisms and clinical implications.
    • G. Oxenkrug
    • Biology, Medicine
    • Annals of the New York Academy of Sciences
    • 2005
    • 40