Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis.

@article{Schmitt1982GeneticAO,
  title={Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis.},
  author={Hans Dieter Schmitt and Friedrich M. Zimmermann},
  journal={Journal of bacteriology},
  year={1982},
  volume={151 3},
  pages={
          1146-52
        }
}
Six different pyruvate decarboxylase mutants of Saccharomyces cerevisiae were isolated. They belong to two unlinked complementation groups. Evidence is presented that one group is affected in a structural gene. The fact that five of the six mutants had residual pyruvate decarboxylase activity provided the opportunity for an intensive physiological characterization. It was shown that the loss of enzyme activity in vitro is reflected in a lower fermentation rate, an increased pyruvate secretion… CONTINUE READING

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Isolation and characterization of a Saccharomyces cerevisiae mutant deficient in pyruvate kinase activity

  • G. F. Sprague, Jr.
  • J. Bacteriol
  • 1977
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