Genetic analysis of the oocyte--a review.

@article{Plachot2003GeneticAO,
  title={Genetic analysis of the oocyte--a review.},
  author={Michelle Plachot},
  journal={Placenta},
  year={2003},
  volume={24 Suppl B},
  pages={S66-9}
}
Chromosome number abnormalities are remarkably common in human reproduction. Most are caused by chromosomal non-disjunction and premature chromatid separation in oocyte meiosis I. Pooled data from previous studies showed that one in five oocytes that failed to fertilize after in vitro insemination was abnormal when analysed by conventional cytogenetics. Preconception genetic diagnosis, carried out on the first and second polar bodies by FISH, using 5 chromosome-specific probes (13, 16, 18, 21… CONTINUE READING