Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.

@article{Jones1990GeneticAO,
  title={Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.},
  author={Richard S Jones and William M. Gelbart},
  journal={Genetics},
  year={1990},
  volume={126 1},
  pages={
          185-99
        }
}
The Enhancer of zeste [E(z)] locus of Drosophila melanogaster is implicated in multiple examples of gene regulation during development. First identified as dominant gain-of-function modifiers of the zeste1-white (z-w) interaction, mutant E(z) alleles also produce homeotic transformations. Reduction of E(z)+ activity leads to both suppression of the z-w interaction and ectopic expression of segment identity genes of the Antennapedia and bithorax gene complexes. This latter effect defines E(z) as… CONTINUE READING

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