Genetic analysis of the b-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to b-lactam antibiotics

@inproceedings{Flores2005GeneticAO,
  title={Genetic analysis of the b-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to b-lactam antibiotics},
  author={Anthony R Flores and Linda M Parsons and Martin S Pavelka},
  year={2005}
}
Received 14 September 2004 Revised 1 November 2004 Accepted 3 November 2004 Mycobacteria produce b-lactamases and are intrinsically resistant to b-lactam antibiotics. In addition to the b-lactamases, cell envelope permeability and variations in certain peptidoglycan biosynthetic enzymes are believed to contribute to b-lactam resistance in these organisms. To allow the study of these additional mechanisms, mutants of the major b-lactamases, BlaC and BlaS, were generated in the pathogenic… CONTINUE READING

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