Genetic analysis of the NAT2 and CYP2D6 polymorphisms in white patients with non-insulin-dependent diabetes mellitus.

@article{Agndez1996GeneticAO,
  title={Genetic analysis of the NAT2 and CYP2D6 polymorphisms in white patients with non-insulin-dependent diabetes mellitus.},
  author={Jos{\'e} A. G. Ag{\'u}ndez and J. M. Garc{\'i}a Menaya and R Tejeda and Flavio Dal Lago and Margarita Ch{\'a}vez and Julio Cesar Munoz Benitez},
  journal={Pharmacogenetics},
  year={1996},
  volume={6 5},
  pages={465-72}
}
The arylamine N-acetyltransferase (NAT2) polymorphism has been related to the risk of developing non-insulin-dependent diabetes mellitus (NIDDM). Several studies suggested an excess of rapid acetylators among NIDDM patients. This may be explained by an increased risk to develop NIDDM among subjects with the rapid acetylator capacity, or by changes in the acetylator status due to the disease or drug therapy. In order to elucidate this controversial topic, we have studied by a mutation-specific… CONTINUE READING