Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

  title={Genetic analysis of the M{\"u}llerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.},
  author={Yuji Mishina and R. P{\'e}rez Rey and Milton J. Finegold and Martin M. Matzuk and Nathalie Josso and Richard L. Cate and Richard R. Behringer},
  journal={Genes & development},
  volume={10 20},
Müllerian-inhibiting substance (MIS) is a member of the transforming growth factor-beta (TGF-beta) gene family. MIS expression in males causes the regression of the Müllerian ducts, an essential process in male sexual differentiation. Recently, an MIS type II receptor gene has been isolated that is expressed during embryogenesis in mesenchymal cells adjacent to the Müllerian duct epithelium and in Sertoli and granulosa cells of the fetal and adult, male and female gonads, respectively. MIS… CONTINUE READING